Regulation of immunoglobulin production

Across TCGA patient cohorts, RNA activity of the Regulation of immunoglobulin production pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAPGEF3, CHEK2, and ARHGAP11B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of immunoglobulin production activity versus RAPGEF3 in HNSC (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RAPGEF3 →	-0.708	-0.610	<.001	<.001	3	7
BRCA	CHEK2 →	+0.546	+0.532	.001	.002	3	7
LUAD	ARHGAP11B →	+0.443	+0.224	<.001	<.001	3	7
BRCA	SGO1 →	+0.788	+0.444	<.001	<.001	3	6
OV	BRIP1 →	+0.934	+0.717	<.001	<.001	3	6
BRCA	KIF11 →	+0.938	+0.669	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002637 vs RAPGEF3 — HNSC

Explore this scatter interactively →