Regulation of immunoglobulin production

Across TCGA cell cohorts, RNA activity of the Regulation of immunoglobulin production pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBX2, TBC1D3B, and CEP68, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of immunoglobulin production activity versus CBX2 in SOFT_TISSUE (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CBX2 →	+2.588	+0.295	<.001	.006	3	6
SKIN	TBC1D3B →	+0.453	+0.159	.003	.004	3	5
SOFT_TISSUE	CEP68 →	+0.826	+0.242	.008	.004	2	6
PANCREAS	RTF1 →	+0.480	+0.170	.001	.004	3	5
PANCREAS	MTF2 →	+0.755	+0.269	<.001	<.001	3	5
PANCREAS	SEMA6C →	+0.770	+0.172	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002637 vs CBX2 — SOFT_TISSUE

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