Positive regulation of dendritic cell antigen processing and presentation

Across TCGA cell cohorts, RNA activity of the Positive regulation of dendritic cell antigen processing and presentation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VAMP3, PLEKHO1, and SYPL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VAMP3 grouped by Positive regulation of dendritic cell antigen processing and presentation-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	VAMP3 →	-1.006	-1.470	.002	.001	3	5
STOMACH	PLEKHO1 →	+1.797	+0.824	.006	.002	3	4
STOMACH	SYPL1 →	-1.482	-1.142	.001	.002	3	4
CNS	SDCBP →	-0.852	-1.007	.009	.002	3	4
CNS	TACC1 →	-1.668	-1.341	.001	<.001	3	4
SKIN	PSMC2 →	-0.464	-0.861	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VAMP3 by Positive regulation of dendritic cell antigen processing and presentation activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →