Regulation of dendritic cell antigen processing and presentation

Across TCGA cell cohorts, RNA activity of the Regulation of dendritic cell antigen processing and presentation pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF621, CRK, and COX4I1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF621 grouped by Regulation of dendritic cell antigen processing and presentation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF621 →	+0.184	+0.625	<.001	.009	3	5
KIDNEY	CRK →	+0.397	+0.292	.002	.004	3	5
LUNG_NSCLC_LUAD	COX4I1 →	-0.242	-0.710	.001	.005	3	5
LUNG_NSCLC_LUAD	PDLIM4 →	-0.155	-0.641	<.001	.002	3	5
SOFT_TISSUE	PKN2 →	+0.275	+1.564	.002	<.001	3	5
SOFT_TISSUE	PHKA1 →	+0.210	+1.446	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF621 by Regulation of dendritic cell antigen processing and presentation activity — LARGE_INTESTINE

Explore this box plot interactively →