Regulation of dendritic cell antigen processing and presentation

Across TCGA cell cohorts, RNA activity of the Regulation of dendritic cell antigen processing and presentation pathway is significantly associated with the drug response of multiple features, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Cisplatin, SB216763, and VSP34_8731, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Cisplatin grouped by Regulation of dendritic cell antigen processing and presentation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Cisplatin →	+0.406	+0.494	.048	.011	3	1
BLOOD_Leukemia	SB216763 →	+0.620	+0.595	.003	.005	3	1
BLOOD_Leukemia	VSP34_8731 →	+0.450	+0.495	.013	.011	3	1
BLOOD_Leukemia	Telomerase Inhibitor IX →	+0.393	+0.562	.010	.012	3	1
BLOOD_Leukemia	Mycophenolic acid →	+0.629	+0.494	.001	.011	3	1
BLOOD_Leukemia	CP724714 →	+0.378	+0.498	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Cisplatin by Regulation of dendritic cell antigen processing and presentation activity — BLOOD_Leukemia

Explore this box plot interactively →