Negative regulation of antigen processing and presentation

Across TCGA cell cohorts, RNA activity of the Negative regulation of antigen processing and presentation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCT4, RAPGEF6, and EXOSC3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCT4 grouped by Negative regulation of antigen processing and presentation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCT4 →	-0.743	-0.922	.001	.007	3	4
BONE	RAPGEF6 →	+0.543	+1.753	.008	<.001	3	4
OESOPHAGUS	EXOSC3 →	-0.948	-0.944	.002	.007	2	4
LUNG_NSCLC_LUAD	MKKS →	+0.883	+0.977	<.001	.006	3	3
LUNG_NSCLC_LUAD	DCUN1D5 →	-0.491	-1.005	.005	.001	3	3
LUNG_NSCLC_LUAD	MELK →	-0.839	-1.010	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCT4 by Negative regulation of antigen processing and presentation activity — LARGE_INTESTINE

Explore this box plot interactively →