Negative regulation of antigen processing and presentation

Across TCGA cell cohorts, RNA activity of the Negative regulation of antigen processing and presentation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTNND1, RBM3, and BET1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of antigen processing and presentation activity versus CTNND1 in BLOOD_Lymphoma (Pearson r = -0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CTNND1 →	-1.626	-1.928	.003	<.001	3	2
BLOOD_Lymphoma	RBM3 →	-0.787	-1.928	<.001	<.001	3	1
BLOOD_Lymphoma	BET1 →	+0.468	+1.928	.003	<.001	3	1
BLOOD_Lymphoma	CHCHD2 →	+0.720	+1.928	.007	<.001	3	1
BLOOD_Lymphoma	COA1 →	+1.092	+1.928	<.001	<.001	3	1
BLOOD_Lymphoma	RHEB →	+0.892	+1.928	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002578 vs CTNND1 — BLOOD_Lymphoma

Explore this scatter interactively →