Regulation of antigen processing and presentation

Across TCGA patient cohorts, RNA activity of the Regulation of antigen processing and presentation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIM21, HLA-DPA1, and CD3E, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of antigen processing and presentation activity versus TRIM21 in GBM (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TRIM21 →	+0.350	+0.183	<.001	<.001	3	6
GBM	HLA-DPA1 →	+1.015	+0.233	<.001	<.001	3	6
GBM	CD3E →	+1.801	+0.368	<.001	<.001	3	5
GBM	DEF6_S590 →	+0.848	+0.291	<.001	<.001	3	5
GBM	EVI2B_S268 →	+0.680	+0.253	<.001	<.001	3	5
UCEC	ITGAL →	+0.612	+0.226	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002577 vs TRIM21 — GBM

Explore this scatter interactively →