Regulation of antigen processing and presentation

Across TCGA cell cohorts, RNA activity of the Regulation of antigen processing and presentation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DIPK1B, GALE, and ENDOD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DIPK1B grouped by Regulation of antigen processing and presentation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DIPK1B →	+1.502	+0.723	.001	.003	3	4
UPPER_AERODIGESTIVE_TRACT	GALE →	-1.036	-0.724	<.001	<.001	3	4
KIDNEY	ENDOD1 →	-1.038	-0.583	.002	.007	3	4
KIDNEY	HIGD1A →	-1.115	-0.453	<.001	.002	3	4
LUNG_NSCLC_LUAD	SATL1 →	+0.091	+0.637	.005	.006	2	5
BREAST	OSGIN1 →	-1.125	-0.565	.001	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DIPK1B by Regulation of antigen processing and presentation activity — PANCREAS

Explore this box plot interactively →