Platelet degranulation

Across TCGA patient cohorts, RNA activity of the Platelet degranulation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMSN1, SYK, and DOCK11, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Platelet degranulation activity versus SAMSN1 in UCEC (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SAMSN1 →	+0.534	+0.138	<.001	<.001	3	6
BRCA	SYK →	+0.441	+0.063	<.001	<.001	3	6
UCEC	DOCK11 →	+0.335	+0.083	<.001	<.001	3	6
LSCC	DOCK2_S1706 →	+0.668	+0.059	<.001	<.001	3	6
LUAD	NPC2 →	+0.683	+0.114	<.001	<.001	3	6
BRCA	KCNAB2_S9 →	+0.577	+0.065	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002576 vs SAMSN1 — UCEC

Explore this scatter interactively →