Platelet degranulation

Across TCGA cell cohorts, RNA activity of the Platelet degranulation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMN1, EPCAM, and NOXA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMN1 grouped by Platelet degranulation-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SMN1 →	+0.891	+1.429	.001	<.001	3	4
STOMACH	EPCAM →	+4.276	+0.936	.003	.008	3	4
STOMACH	NOXA1 →	+1.526	+1.224	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	AP1S3 →	+1.454	+1.710	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	FEZ2 →	+1.423	+1.470	.004	<.001	3	4
KIDNEY	BORCS6 →	+0.544	+1.286	.008	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMN1 by Platelet degranulation activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →