Platelet degranulation

Across TCGA cell cohorts, RNA activity of the Platelet degranulation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO10, KCTD3, and AKAP7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Platelet degranulation activity versus FBXO10 in BLOOD_Lymphoma (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FBXO10 →	+0.899	+0.875	.008	.007	2	5
BLOOD_Lymphoma	KCTD3 →	-2.288	-1.164	<.001	.004	3	3
BLOOD_Lymphoma	AKAP7 →	-1.122	-0.933	.001	.003	3	3
BLOOD_Lymphoma	C22orf23 →	-0.439	-1.190	.009	.002	3	3
BLOOD_Lymphoma	GAREM1 →	-0.869	-1.253	.006	.001	3	3
KIDNEY	VPS54 →	-0.580	-0.431	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002576 vs FBXO10 — BLOOD_Lymphoma

Explore this scatter interactively →