Myeloid leukocyte differentiation

Across TCGA patient cohorts, RNA activity of the Myeloid leukocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF660, KLHL3, and PDCD4, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myeloid leukocyte differentiation activity versus ZNF660 in BRCA (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF660 →	-1.371	-0.329	<.001	.005	3	1
BRCA	KLHL3 →	-1.739	-0.329	.008	.005	3	1
BRCA	PDCD4 →	-1.718	-0.329	.004	.005	3	1
BRCA	COX6CP14 →	-0.836	-0.244	<.001	.004	3	1
BRCA	RN7SL559P →	-0.943	-0.287	.007	.001	3	1
COAD	OGG1 →	-0.402	-0.183	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002573 vs ZNF660 — BRCA

Explore this scatter interactively →