Myeloid leukocyte differentiation

Across TCGA cell cohorts, RNA activity of the Myeloid leukocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS26A, KCTD10, and RPP30, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VPS26A grouped by Myeloid leukocyte differentiation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	VPS26A →	-0.716	-0.292	.003	.002	3	4
STOMACH	KCTD10 →	-1.054	-0.262	<.001	<.001	3	4
LIVER	RPP30 →	-0.928	-0.299	.002	.002	3	4
LIVER	FSTL1 →	-4.353	-0.333	.001	.001	3	4
LIVER	ABCC6 →	+2.686	+0.311	.002	.002	3	4
CNS	SEPTIN3 →	+1.335	+0.127	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VPS26A by Myeloid leukocyte differentiation activity — LIVER

Explore this box plot interactively →