Myeloid leukocyte differentiation

Across TCGA cell cohorts, RNA activity of the Myeloid leukocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLOD2, TUBD1, and CDKN1C, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myeloid leukocyte differentiation activity versus PLOD2 in LARGE_INTESTINE (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLOD2 →	+1.652	+0.137	.002	.005	3	6
BONE	TUBD1 →	+0.980	+0.232	.001	.002	3	4
BLOOD_Leukemia	CDKN1C →	-1.099	-0.167	.002	.002	3	4
BLOOD_Lymphoma	LRRC8C →	+1.716	+0.192	<.001	.002	3	4
BLOOD_Lymphoma	SPIB →	-3.962	-0.147	<.001	.005	3	4
BLOOD_Lymphoma	CYFIP2 →	-1.353	-0.195	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002573 vs PLOD2 — LARGE_INTESTINE

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