Monocyte chemotaxis

Across TCGA cell cohorts, RNA activity of the Monocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MACO1, SCD5, and IGSF8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MACO1 grouped by Monocyte chemotaxis-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MACO1 →	+0.899	+0.420	.001	.001	3	3
LUNG_NSCLC_LUAD	SCD5 →	+1.732	+0.520	<.001	.005	3	3
KIDNEY	IGSF8 →	+0.768	+0.408	.001	.006	3	3
BLOOD_Leukemia	TMEM201 →	+0.572	+0.714	<.001	.007	3	3
BLOOD_Leukemia	CDC6 →	+0.951	+0.928	.001	.006	3	3
UPPER_AERODIGESTIVE_TRACT	BNIP3L →	+1.155	+0.415	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MACO1 by Monocyte chemotaxis activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →