Monocyte chemotaxis

Across TCGA cell cohorts, RNA activity of the Monocyte chemotaxis pathway is significantly associated with the protein abundance of multiple proteins, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANXA1, LGALS3, and ANXA2, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monocyte chemotaxis activity versus ANXA1 in SOFT_TISSUE (Pearson r = 0.72).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ANXA1 →	+4.740	+0.410	<.001	<.001	3	16
CNS	LGALS3 →	+2.756	+0.347	<.001	<.001	3	15
BLOOD_Lymphoma	ANXA2 →	+3.027	+0.225	<.001	.002	2	13
URINARY_TRACT	ACTN4 →	+2.193	+0.288	<.001	.001	3	11
URINARY_TRACT	PLS3 →	+2.218	+0.354	<.001	<.001	3	11
URINARY_TRACT	NIBAN2 →	+1.590	+0.373	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002548 vs ANXA1 — SOFT_TISSUE

Explore this scatter interactively →