Chronic inflammatory response

Across TCGA patient cohorts, RNA activity of the Chronic inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SP140, IL18RAP, and KLHL6, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chronic inflammatory response activity versus SP140 in HNSC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SP140 →	+0.691	+0.178	.001	<.001	3	10
GBM	IL18RAP →	+0.881	+0.198	<.001	<.001	3	9
LSCC	KLHL6 →	+0.925	+0.287	<.001	<.001	3	9
BRCA	CCL5 →	+1.549	+0.416	<.001	<.001	3	9
LSCC	LILRB1 →	+1.040	+0.351	<.001	<.001	3	8
UCEC	BIN2 →	+0.920	+0.243	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002544 vs SP140 — HNSC

Explore this scatter interactively →