Chronic inflammatory response

Across TCGA cell cohorts, RNA activity of the Chronic inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TESK2, C11orf49, and ING1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TESK2 grouped by Chronic inflammatory response-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TESK2 →	-0.823	-0.935	.001	.006	3	5
URINARY_TRACT	C11orf49 →	+1.263	+1.816	<.001	<.001	3	4
URINARY_TRACT	ING1 →	+0.876	+1.626	.001	<.001	3	4
BREAST	RNF145 →	+1.235	+0.743	.003	.001	3	4
BREAST	CHTF8 →	+0.659	+0.861	.003	.004	3	4
LIVER	PSMD9 →	+0.741	+1.661	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TESK2 by Chronic inflammatory response activity — LARGE_INTESTINE

Explore this box plot interactively →