Chronic inflammatory response

Across TCGA cell cohorts, RNA activity of the Chronic inflammatory response pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYH7, ITGAM, and GPR39, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYH7 grouped by Chronic inflammatory response-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYH7 →	-0.207	-1.117	.007	.003	3	4
LARGE_INTESTINE	ITGAM →	-0.240	-0.960	.003	.003	3	4
LUNG_NSCLC_LUAD	GPR39 →	-0.144	-0.851	.005	.001	3	4
LUNG_SCLC	HYAL3 →	+0.217	+1.672	.006	<.001	3	4
LUNG_SCLC	GPAA1 →	-0.296	-1.661	<.001	.001	3	4
OESOPHAGUS	AAR2 →	-0.150	-0.296	.009	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYH7 by Chronic inflammatory response activity — BLOOD_Leukemia

Explore this box plot interactively →