Chronic inflammatory response

Across TCGA cell cohorts, RNA activity of the Chronic inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFKBIZ, CEBPB, and RBBP4, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chronic inflammatory response activity versus NFKBIZ in STOMACH (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	NFKBIZ →	+2.440	+1.291	<.001	<.001	3	15
LUNG_SCLC	CEBPB →	+1.918	+1.154	<.001	.002	3	13
BLOOD_Lymphoma	RBBP4 →	-0.892	-0.495	<.001	.005	3	11
STOMACH	THBS1 →	+3.206	+0.833	<.001	<.001	3	9
BLOOD_Leukemia	S100A9 →	+4.523	+0.656	<.001	<.001	3	9
BONE	CDCA7 →	-1.684	-0.607	.008	.004	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002544 vs NFKBIZ — STOMACH

Explore this scatter interactively →