Production of molecular mediator involved in inflammatory response

Across TCGA patient cohorts, RNA activity of the Production of molecular mediator involved in inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIK3R5, LILRB3, and FGR, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Production of molecular mediator involved in inflammatory response activity versus PIK3R5 in GBM (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PIK3R5 →	+0.926	+0.197	<.001	<.001	3	10
GBM	LILRB3 →	+0.779	+0.157	<.001	<.001	3	10
OV	FGR →	+0.913	+0.204	<.001	<.001	3	10
BRCA	LILRB1 →	+0.815	+0.189	<.001	<.001	3	10
BRCA	ARHGAP9 →	+0.865	+0.192	<.001	<.001	3	10
GBM	LCP2 →	+0.855	+0.161	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002532 vs PIK3R5 — GBM

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