Production of molecular mediator involved in inflammatory response

Across TCGA cell cohorts, RNA activity of the Production of molecular mediator involved in inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CALML4, MT-ND6, and MLF2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CALML4 grouped by Production of molecular mediator involved in inflammatory response-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CALML4 →	+0.894	+0.957	.001	.009	3	4
SKIN	MT-ND6 →	+0.695	+1.182	.005	.001	3	4
SKIN	MLF2 →	-0.425	-1.301	.004	.001	3	4
CNS	CCT8 →	-0.589	-0.987	<.001	<.001	3	3
BLOOD_Myeloma	ID1 →	+2.512	+1.952	<.001	<.001	3	3
BLOOD_Myeloma	POMZP3 →	-1.045	-1.391	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CALML4 by Production of molecular mediator involved in inflammatory response activity — LUNG_SCLC

Explore this box plot interactively →