Production of molecular mediator involved in inflammatory response

Across TCGA cell cohorts, RNA activity of the Production of molecular mediator involved in inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UQCC3, SNAP23, and HADHA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Production of molecular mediator involved in inflammatory response activity versus UQCC3 in STOMACH (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	UQCC3 →	-0.818	-1.602	.004	<.001	3	5
BLOOD_Lymphoma	SNAP23 →	+0.859	+1.271	.001	<.001	2	6
LUNG_NSCLC_LUSC	HADHA →	-1.043	-1.394	.003	.003	3	4
BLOOD_Leukemia	DENND4B →	+0.565	+1.042	.005	.002	2	5
SOFT_TISSUE	NBEAL1 →	+0.685	+1.584	.008	<.001	3	3
SOFT_TISSUE	SKIL →	+1.505	+1.633	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002532 vs UQCC3 — STOMACH

Explore this scatter interactively →