Hypersensitivity

Across TCGA patient cohorts, RNA activity of the Hypersensitivity pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF2RB, BIN2, and SIGLEC10, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hypersensitivity activity versus CSF2RB in BRCA (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CSF2RB →	+1.239	+0.616	<.001	<.001	3	9
HNSC	BIN2 →	+0.956	+0.573	<.001	<.001	3	9
GBM	SIGLEC10 →	+1.261	+0.397	<.001	<.001	3	9
HNSC	PIK3CG →	+0.731	+0.498	<.001	<.001	3	9
BRCA	SP140 →	+0.959	+0.628	<.001	<.001	3	9
GBM	ARHGAP9 →	+1.030	+0.460	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002524 vs CSF2RB — BRCA

Explore this scatter interactively →