Hypersensitivity

Across TCGA cell cohorts, RNA activity of the Hypersensitivity pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KDM1A, ACLY, and RHBDD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KDM1A grouped by Hypersensitivity-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KDM1A →	+0.324	+1.102	.001	.008	3	4
PANCREAS	ACLY →	-0.277	-1.317	.003	.003	3	3
PANCREAS	RHBDD1 →	-0.137	-1.217	.005	.009	3	3
PANCREAS	IQGAP3 →	+0.170	+1.142	.004	.003	3	3
PANCREAS	SLX4 →	+0.192	+1.751	<.001	.001	3	3
PANCREAS	PSG1 →	+0.249	+1.441	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KDM1A by Hypersensitivity activity — OVARY

Explore this box plot interactively →