Immune system development

Across TCGA patient cohorts, RNA activity of the Immune system development pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADPRH, GMIP, and ARHGAP30, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Immune system development activity versus ADPRH in HNSC (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ADPRH →	+0.485	+0.046	<.001	<.001	3	9
LSCC	GMIP →	+0.326	+0.025	<.001	.001	3	9
LSCC	ARHGAP30 →	+0.484	+0.025	<.001	.002	3	9
BRCA	PTPN6 →	+0.578	+0.031	<.001	<.001	3	9
GBM	EVL →	+0.480	+0.026	<.001	<.001	3	9
LSCC	THEMIS2_T593 →	+0.631	+0.019	<.001	.006	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002520 vs ADPRH — HNSC

Explore this scatter interactively →