Immune system development

Across TCGA patient cohorts, RNA activity of the Immune system development pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAD2L1P1, CSE1L, and FLVCR1-DT, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Immune system development activity versus MAD2L1P1 in COAD (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MAD2L1P1 →	+0.529	+0.536	.001	.009	3	2
BRCA	CSE1L →	+1.246	+0.176	.003	.006	2	3
BRCA	FLVCR1-DT →	+1.284	+0.186	.005	.006	3	2
COAD	SHH →	-0.961	-0.503	<.001	.001	3	1
COAD	CFAP65 →	-0.261	-0.625	<.001	.006	3	1
COAD	RPL23AP38 →	+0.216	+0.479	.004	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002520 vs MAD2L1P1 — COAD

Explore this scatter interactively →