Immune system development

Across TCGA cell cohorts, RNA activity of the Immune system development pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO10, AGO1, and LCA5L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FBXO10 grouped by Immune system development-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FBXO10 →	+0.660	+0.181	.003	.005	3	4
CNS	AGO1 →	+0.539	+0.229	.004	<.001	3	4
BLOOD_Leukemia	LCA5L →	+0.540	+0.220	.006	.006	2	5
LUNG_NSCLC_LUSC	ZFYVE19 →	+0.548	+0.178	.003	.003	3	4
OESOPHAGUS	HELB →	+0.592	+0.192	.004	<.001	3	4
LARGE_INTESTINE	ZNF852 →	+0.737	+0.099	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FBXO10 by Immune system development activity — CNS

Explore this box plot interactively →