Tolerance induction to self antigen

pathway activity — cross-omics
GO:0002513Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Tolerance induction to self antigen pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PAXBP1_S262, THAP12_S141, and CRKL_T228, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVPAXBP1_S262 →+0.938+0.772<.001<.00134
GBMTHAP12_S141 →+0.455+0.909<.001<.00133
UCECCRKL_T228 →-1.564-0.956<.001<.00133
CCRCCRASAL3_S819 →+0.591+0.627.001.00233
GBMRBBP6_S516 →+0.606+0.823<.001.00133
CCRCCRGS19_S65 →+1.331+1.424.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration