Antigen processing and presentation of endogenous peptide antigen

Across TCGA patient cohorts, RNA activity of the Antigen processing and presentation of endogenous peptide antigen pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL2RB, SLC15A3, and BTN3A3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antigen processing and presentation of endogenous peptide antigen activity versus IL2RB in BRCA (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IL2RB →	+1.260	+0.279	<.001	<.001	3	10
OV	SLC15A3 →	+0.760	+0.210	.004	.005	3	10
COAD	BTN3A3 →	+1.030	+0.238	<.001	<.001	3	10
HNSC	GBP1 →	+1.607	+0.304	<.001	<.001	3	10
HNSC	IRF1 →	+0.965	+0.275	<.001	<.001	3	10
HNSC	CXCL9 →	+2.306	+0.254	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002483 vs IL2RB — BRCA

Explore this scatter interactively →