Antigen processing and presentation of endogenous peptide antigen

Across TCGA patient cohorts, RNA activity of the Antigen processing and presentation of endogenous peptide antigen pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TAP1, TAP2, and TAPBP, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antigen processing and presentation of endogenous peptide antigen activity versus TAP1 in CCRCC (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TAP1 →	+0.689	+0.195	<.001	<.001	3	10
PDAC	TAP2 →	+0.897	+0.321	<.001	<.001	3	10
UCEC	TAPBP →	+0.778	+0.332	<.001	<.001	3	10
UCEC	GBP1 →	+0.851	+0.343	<.001	<.001	3	10
UCEC	GBP4 →	+0.675	+0.362	<.001	<.001	3	10
GBM	GBP5 →	+1.019	+0.250	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002483 vs TAP1 — CCRCC

Explore this scatter interactively →