Antigen processing and presentation of endogenous peptide antigen

Across TCGA cell cohorts, RNA activity of the Antigen processing and presentation of endogenous peptide antigen pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UHRF1BP1L, C8orf37, and GFM1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UHRF1BP1L grouped by Antigen processing and presentation of endogenous peptide antigen-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	UHRF1BP1L →	+1.148	+0.863	<.001	.005	3	3
PANCREAS	C8orf37 →	+0.475	+0.534	.004	.002	3	3
PANCREAS	GFM1 →	+0.740	+0.688	<.001	.008	3	3
OESOPHAGUS	LRRC8B →	-1.308	-0.837	<.001	.008	3	3
LUNG_NSCLC_LUAD	MRPS16 →	+0.513	+0.574	.004	.001	3	3
BONE	AKR1E2 →	-2.524	-0.550	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UHRF1BP1L by Antigen processing and presentation of endogenous peptide antigen activity — PANCREAS

Explore this box plot interactively →