Antigen processing and presentation of exogenous peptide antigen

Across TCGA cell cohorts, RNA activity of the Antigen processing and presentation of exogenous peptide antigen pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPM, CGN, and TRIM7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CENPM grouped by Antigen processing and presentation of exogenous peptide antigen-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CENPM →	+0.801	+0.982	.005	.004	3	4
SOFT_TISSUE	CGN →	+1.550	+1.293	.002	.001	3	3
SOFT_TISSUE	TRIM7 →	-1.461	-1.043	.006	.002	3	3
LUNG_SCLC	RMND5B →	+0.721	+1.448	.003	<.001	3	3
LUNG_SCLC	ZNF771 →	+0.700	+1.124	.002	.004	3	3
LIVER	FBXO30 →	+0.809	+1.376	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CENPM by Antigen processing and presentation of exogenous peptide antigen activity — SKIN

Explore this box plot interactively →