Antigen processing and presentation of peptide antigen via MHC class I

Across TCGA patient cohorts, RNA activity of the Antigen processing and presentation of peptide antigen via MHC class I pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIM21, HLA-E, and TRIM22, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antigen processing and presentation of peptide antigen via MHC class I activity versus TRIM21 in GBM (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TRIM21 →	+0.482	+0.077	<.001	<.001	3	10
OV	HLA-E →	+0.546	+0.062	<.001	<.001	3	10
LSCC	TRIM22 →	+0.601	+0.089	<.001	<.001	3	10
OV	ARHGAP25 →	+1.188	+0.105	.007	.003	3	10
GBM	UBA7 →	+0.522	+0.070	<.001	<.001	3	9
LSCC	ANKRD44 →	+0.334	+0.071	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002474 vs TRIM21 — GBM

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