Antigen processing and presentation of peptide antigen via MHC class I

Across TCGA patient cohorts, RNA activity of the Antigen processing and presentation of peptide antigen via MHC class I pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFNG, CXCL9, and TNFSF13B, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antigen processing and presentation of peptide antigen via MHC class I activity versus IFNG in CCRCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	IFNG →	+0.884	+0.211	<.001	<.001	3	10
BRCA	CXCL9 →	+1.629	+0.200	.001	.002	3	10
COAD	TNFSF13B →	+0.990	+0.213	.002	.001	3	9
HNSC	FASLG →	+1.070	+0.225	<.001	<.001	3	9
OV	EPSTI1 →	+1.091	+0.198	<.001	<.001	3	9
LSCC	CD72 →	+0.740	+0.267	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002474 vs IFNG — CCRCC

Explore this scatter interactively →