Antigen processing and presentation of peptide antigen via MHC class I

Across TCGA cell cohorts, RNA activity of the Antigen processing and presentation of peptide antigen via MHC class I pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-C, HLA-A, and PSMB9, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antigen processing and presentation of peptide antigen via MHC class I activity versus HLA-C in LUNG_SCLC (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HLA-C →	+3.511	+0.186	<.001	<.001	3	20
BREAST	HLA-A →	+2.917	+0.149	<.001	<.001	3	20
LIVER	PSMB9 →	+3.883	+0.217	<.001	.001	3	20
SOFT_TISSUE	ERAP1 →	+2.436	+0.256	<.001	<.001	3	19
LIVER	TAP1 →	+3.515	+0.279	<.001	<.001	3	19
SOFT_TISSUE	PSMB8 →	+4.694	+0.225	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002474 vs HLA-C — LUNG_SCLC

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