Tolerance induction dependent upon immune response

Across TCGA patient cohorts, RNA activity of the Tolerance induction dependent upon immune response pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WARS1, GBP5, and ITGAX, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tolerance induction dependent upon immune response activity versus WARS1 in HNSC (Pearson r = 0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	WARS1 →	+1.175	+0.177	<.001	<.001	3	10
HNSC	GBP5 →	+1.385	+0.249	<.001	.001	3	10
UCEC	ITGAX →	+0.686	+0.775	<.001	<.001	3	10
UCEC	LCP2 →	+0.664	+0.839	<.001	<.001	3	10
BRCA	ITGAL →	+0.697	+0.098	<.001	<.001	3	10
HNSC	LAP3 →	+1.001	+0.283	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002461 vs WARS1 — HNSC

Explore this scatter interactively →