Tolerance induction dependent upon immune response

Across TCGA patient cohorts, RNA activity of the Tolerance induction dependent upon immune response pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF5LP1, RASSF4, and TNFSF13B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tolerance induction dependent upon immune response activity versus TAF5LP1 in HNSC (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TAF5LP1 →	+0.907	+0.223	.009	.004	3	8
BRCA	RASSF4 →	+0.777	+0.228	.002	<.001	3	8
HNSC	TNFSF13B →	+1.000	+0.252	.003	.001	3	7
UCEC	TFEC →	+1.474	+0.464	.002	.001	2	8
HNSC	GPR174 →	+1.360	+0.276	<.001	.006	3	7
OV	CXCR3 →	+1.614	+0.167	.006	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002461 vs TAF5LP1 — HNSC

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