Tolerance induction dependent upon immune response

Across TCGA cell cohorts, RNA activity of the Tolerance induction dependent upon immune response pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFKBIE, MYO1H, and TM2D2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NFKBIE grouped by Tolerance induction dependent upon immune response-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NFKBIE →	+0.848	+1.140	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	MYO1H →	-0.129	-1.050	.006	.004	3	4
LARGE_INTESTINE	TM2D2 →	+0.838	+0.867	.005	.003	3	3
LARGE_INTESTINE	ANKRD18B →	+1.173	+1.226	<.001	<.001	3	3
LUNG_SCLC	CNPY4 →	+0.750	+0.969	<.001	.008	3	3
CNS	TTC39B →	-0.552	-0.800	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NFKBIE by Tolerance induction dependent upon immune response activity — LARGE_INTESTINE

Explore this box plot interactively →