Tolerance induction dependent upon immune response

Across TCGA cell cohorts, RNA activity of the Tolerance induction dependent upon immune response pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MT1A, ZNF620, and TAS2R1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MT1A grouped by Tolerance induction dependent upon immune response-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MT1A →	-0.109	-0.592	<.001	.007	3	4
LUNG_SCLC	ZNF620 →	-0.148	-0.161	.002	.001	3	3
BREAST	TAS2R1 →	-0.111	-0.700	.008	.009	3	3
BLOOD_Lymphoma	HSD17B4 →	-0.273	-0.143	.006	.006	3	3
BLOOD_Leukemia	RCOR1 →	+0.493	+1.120	<.001	.008	2	3
LUNG_NSCLC_LUSC	SLC25A51 →	+0.162	+0.268	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MT1A by Tolerance induction dependent upon immune response activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →