T cell mediated immunity

Across TCGA patient cohorts, RNA activity of the T cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL10RA, CD69, and BIN2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell mediated immunity activity versus IL10RA in LSCC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IL10RA →	+0.927	+0.342	<.001	<.001	3	10
LSCC	CD69 →	+1.044	+0.324	<.001	<.001	3	10
LSCC	BIN2 →	+0.885	+0.372	<.001	<.001	3	10
OV	CYTIP →	+1.049	+0.207	<.001	<.001	3	10
BRCA	SLAMF1 →	+0.970	+0.249	<.001	<.001	3	10
LSCC	LY9 →	+0.701	+0.342	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002456 vs IL10RA — LSCC

Explore this scatter interactively →