T cell mediated immunity

Across TCGA cell cohorts, RNA activity of the T cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPT, SNX22, and SYNPO, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAPT grouped by T cell mediated immunity-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MAPT →	+2.162	+1.198	<.001	<.001	3	5
LUNG_SCLC	SNX22 →	+1.335	+1.216	.005	.002	3	4
LUNG_SCLC	SYNPO →	-1.762	-1.296	.005	<.001	3	4
LUNG_SCLC	ZNF664 →	+1.268	+1.555	.001	<.001	3	4
SKIN	PIP4K2C →	+0.497	+1.070	<.001	<.001	3	4
LARGE_INTESTINE	TBC1D14 →	+0.611	+0.964	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAPT by T cell mediated immunity activity — BREAST

Explore this box plot interactively →