T cell mediated immunity

Across TCGA cell cohorts, RNA activity of the T cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLCG1, CCDC138, and DNAJB7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell mediated immunity activity versus PLCG1 in BLOOD_Leukemia (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PLCG1 →	-1.824	-0.187	.001	.004	3	5
BLOOD_Leukemia	CCDC138 →	-1.252	-0.227	.003	<.001	3	5
BLOOD_Leukemia	DNAJB7 →	-0.103	-0.217	.003	.001	3	5
LUNG_NSCLC_LUSC	EPS8L1 →	+2.500	+0.239	.002	.006	3	5
OESOPHAGUS	HRK →	-1.002	-0.308	<.001	.009	3	4
URINARY_TRACT	MIOS →	-0.638	-0.325	.008	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002456 vs PLCG1 — BLOOD_Leukemia

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