Humoral immune response mediated by circulating immunoglobulin

Across TCGA patient cohorts, RNA activity of the Humoral immune response mediated by circulating immunoglobulin pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EBF1, CD93, and COL5A1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Humoral immune response mediated by circulating immunoglobulin activity versus EBF1 in BRCA (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EBF1 →	+0.767	+0.206	<.001	<.001	3	10
OV	CD93 →	+1.178	+0.338	<.001	<.001	3	9
OV	COL5A1 →	+1.603	+0.217	<.001	<.001	3	9
COAD	MYL9 →	+0.919	+0.258	<.001	<.001	3	8
OV	RHOJ →	+0.890	+0.316	<.001	<.001	3	8
OV	PLVAP →	+1.244	+0.298	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002455 vs EBF1 — BRCA

Explore this scatter interactively →