Humoral immune response mediated by circulating immunoglobulin

Across TCGA cell cohorts, RNA activity of the Humoral immune response mediated by circulating immunoglobulin pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKD2L2, SERPINB8, and HOXD9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PKD2L2 grouped by Humoral immune response mediated by circulating immunoglobulin-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PKD2L2 →	-0.263	-0.304	.007	.003	2	6
BLOOD_Leukemia	SERPINB8 →	-0.254	-0.525	<.001	.005	3	4
BLOOD_Myeloma	HOXD9 →	-0.217	-1.496	.002	<.001	3	4
LUNG_NSCLC_LUAD	TSPO →	-0.207	-0.475	<.001	.002	3	4
BLOOD_Myeloma	GTPBP1 →	-0.343	-1.516	.003	<.001	3	3
BREAST	FUBP3 →	-0.175	-0.464	.007	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PKD2L2 by Humoral immune response mediated by circulating immunoglobulin activity — LUNG_SCLC

Explore this box plot interactively →