Humoral immune response mediated by circulating immunoglobulin

Across TCGA cell cohorts, RNA activity of the Humoral immune response mediated by circulating immunoglobulin pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP3CA, RELL2, and COX10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Humoral immune response mediated by circulating immunoglobulin activity versus PPP3CA in BLOOD_Leukemia (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PPP3CA →	+1.064	+0.276	.001	.005	3	4
STOMACH	RELL2 →	+1.333	+1.766	.001	<.001	2	4
STOMACH	COX10 →	-1.250	-1.929	<.001	<.001	3	3
BONE	MFSD8 →	+0.701	+2.000	.007	<.001	3	3
BLOOD_Lymphoma	SRRD →	+1.037	+0.931	.001	.006	2	4
BLOOD_Lymphoma	MCAT →	+0.575	+1.196	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002455 vs PPP3CA — BLOOD_Leukemia

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