Mast cell mediated immunity

Across TCGA cell cohorts, RNA activity of the Mast cell mediated immunity pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAPZB, SPRR2G, and ACOT11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAPZB grouped by Mast cell mediated immunity-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CAPZB →	+0.278	+0.896	.006	.005	3	3
BLOOD_Leukemia	SPRR2G →	-0.270	-1.997	.007	<.001	3	3
LUNG_SCLC	ACOT11 →	+0.316	+1.322	.006	.006	3	3
LIVER	PLAT →	-0.238	-1.784	.004	<.001	3	3
LIVER	TBX4 →	-0.120	-1.742	.002	<.001	3	3
LIVER	CDKN2B →	-0.204	-1.784	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAPZB by Mast cell mediated immunity activity — PANCREAS

Explore this box plot interactively →