Mast cell mediated immunity

Across TCGA cell cohorts, RNA activity of the Mast cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP26B1, FOXP1, and SNAP23, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mast cell mediated immunity activity versus CYP26B1 in LUNG_SCLC (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CYP26B1 →	-1.740	-0.925	.001	.004	3	5
BREAST	FOXP1 →	+0.954	+1.144	.009	<.001	2	6
BREAST	SNAP23 →	+0.728	+1.099	.001	<.001	3	4
PANCREAS	TBPL1 →	+0.834	+1.158	.002	.003	3	4
BLOOD_Leukemia	PRDM4 →	+0.525	+1.051	.001	<.001	3	4
CNS	RNASET2 →	+0.757	+0.735	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002448 vs CYP26B1 — LUNG_SCLC

Explore this scatter interactively →