Eosinophil mediated immunity

Across TCGA patient cohorts, RNA activity of the Eosinophil mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HCFC2, SLC25A21, and MAGI3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Eosinophil mediated immunity activity versus HCFC2 in GBM (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HCFC2 →	-0.287	-0.692	.002	.005	3	4
HNSC	SLC25A21 →	-0.407	-0.423	.004	.003	3	3
HNSC	MAGI3 →	-0.598	-0.585	<.001	.001	3	3
PDAC	DTWD1 →	-0.358	-0.749	<.001	.002	3	3
LUAD	FRMPD2B →	-0.530	-0.449	.006	.005	3	3
PDAC	OIP5-AS1 →	-0.368	-0.629	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002447 vs HCFC2 — GBM

Explore this scatter interactively →